methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate - Names and Identifiers

Name	(+\|-)-Benzyloxycarbonyl-alpha-phosphonoglycine trimethyl ester
Synonyms	N-Cbz-2-Phosphonoglycine trimethyl ester ()-Z-alpha-Phosphonoglycine trimethyl ester (+-)-N-cbz-A-phosphonoglycine trimethyl ester N-Carbobenzoxy-2-phosphonoglycine Trimethyl Ester N-Benzylcarbonyl-alpha-phosphonoglycine trimethyl ester methyl {[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)acetate ()-Methyl 2-benzyloxycarbonylamino-2-(dimethoxyphosphinyl)acetate methyl (2R)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate N-Cbz-2-phosphonoglycine Trimethyl EsterTrimethyl 2-(Carbobenzoxyamino)-2-phosphonoacetateTrimethyl 2-(Cbz-amino)-2-phosphonoacetate
CAS	88568-95-0
EINECS	629-458-5
InChI	InChI=1/C13H18NO7P/c1-18-12(15)11(22(17,19-2)20-3)14-13(16)21-9-10-7-5-4-6-8-10/h4-8,11H,9H2,1-3H3,(H,14,16)/t11-/m1/s1

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate - Physico-chemical Properties

Molecular Formula	C13H18NO7P
Molar Mass	331.26
Density	1.284±0.06 g/cm3(Predicted)
Melting Point	77-80°C(lit.)
Boling Point	480.5±45.0 °C(Predicted)
Flash Point	244.4°C
Solubility	Soluble in methanol.
Vapor Presure	2.16E-09mmHg at 25°C
Appearance	White solid
Color	White
BRN	5764460
pKa	9.42±0.46(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.504
MDL	MFCD00043304

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29242990

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate - Reference Information

Application

a-phosphonoglycinate is white crystalline or crystalline powder at room temperature, it is easy to dissolve in water, partially soluble in ethanol, ether and other organic solvents. (±) benzyloxycarbonyl-a-phosphonylglycine trimethyl Ester is its benzyloxycarbonyl protected product, can be used as a chemical intermediate, covering a wide range of applications, including pesticides, pharmaceuticals, food, animal feed and daily chemicals and other industries.

preparation method

A-phosphonoglycinate trimethyl Ester was added to A round bottom flask, and 10% sodium carbonate aqueous solution was added to stir and dissolve, then dioxane is added, and 10% dioxane solution of 9-fluorenylmethoxycarbonyl chloride is slowly added dropwise into the reaction solution in an ice bath, and the reaction is carried out in an ice bath for 2 hours after completion of the dropwise addition, then react at room temperature for 8 hours, dilute with water, extract with ether
4
times, place the water layer in ice bath, adjust the pH value with concentrated hydrochloric acid to Congo red test paper, in the refrigerator overnight, the white precipitate was extracted with ethyl acetate, the combined organic liquid was washed with water, the organic layer was dried with anhydrous magnesium sulfate, and was dried to obtain (±) benzyloxycarbonyl-A-phosphonylglycine trimethyl ester.

Last Update：2024-04-09 02:00:12

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate

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methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate

(+|-)-Benzyloxycarbonyl-alpha-phosphonoglycine trimethyl ester

CAS: 88568-95-0

Molecular Formula: C13H18NO7P

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate - Names and Identifiers

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate - Physico-chemical Properties

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate - Risk and Safety

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate - Reference Information

Supplier List

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate Request for Quotation

(+|-)-Benzyloxycarbonyl-alpha-phosphonoglycine trimethyl ester

CAS: 88568-95-0

Molecular Formula: C13H18NO7P

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate - Names and Identifiers

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate - Physico-chemical Properties

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate - Risk and Safety

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate - Reference Information

Supplier List

methyl (2S)-{[(benzyloxy)carbonyl]amino}(dimethoxyphosphoryl)ethanoate